Preimplantation Genetic Screening (PGS) and Preimplantation Genetic Diagnosis (PGD)

Having a healthy baby is something all parents hope for. But, what if you could go even further than that? What if you could help ensure the health of not only your child, but your child’s children and many generations to follow?

At Bridge Clinic we offer couples who are undergoing IVF treatment for fertility reasons or couples who prefer to undergo IVF treatment for the option of having their embryos thoroughly examined for specific gene mutations or chromosomal abnormalities, the option of Preimplantation Genetic Screening (PGS) and Preimplantation Genetic Diagnosis (PGD).

Definition:
A process which allows parents to have the option
of detecting potential defects in an embryo within days
after conception.

Known in short as PGS or PGD, tests are performed on day 5 embryos prior to implantation and pregnancy. Offering specialists the opportunity to examine far beyond the superficial appearance of an embryo, PGS and PGD is increasingly being used at fertility institutes around the globe to help couples have healthy babies, no matter what challenges they face.

The method has also been found to dramatically improve the chances of a successful IVF pregnancy. Since PGS / PGD is newly available in Nigeria, many couples undergoing IVF may not be familiar with the procedure and its benefits.

What is PGD?

PGD is a sophisticated reproductive technology used in conjunction with IVF treatment to test early embryos for specific genetic conditions. Read about which genetic conditions HERE.

The process requires in vitro fertilisation (IVF) to obtain a number of oocytes or embryos for evaluation. Studies have shown that PGD cycles are most successful when implemented on 8 or more embryos, with at least 5 graded of good quality by the embryology lab. The process involves removing cells from a day 5 blastocyst (trophectoderm biopsy).

What is PGS?

Preimplantation Genetic Screening (PGS) uses a process closely related to PGD to test embryos for chromosomal abnormalities.

Difference between PGD and PGS?

PGD is often confused with PGS, however the two processes are implemented to establish entirely different results. PGD tests for SPECIFIC genetic conditions, whereas PGS tests for OVERALL chromosomal normalcy in embryos. In other words, PGD is ideal for (but not exclusively available to) prospective parents who have a specific inherited genetic condition that they do not want to pass to their offspring.

Benefits of PGD and PGS

  • PGD is used to test for more than 100 specific genetic conditions
  • Miscarriage rates following PGD are far less than with standard IVF
  • Since the procedure is performed before implantation, couples may feel more comfortable with deciding whether or not to go ahead with the pregnancy, should results not be favourable
  • The procedure enables couples who may be at risk of passing genetic conditions to their children the opportunity of pursuing biological parenthood, which they may not have done otherwise
  • Offering the option of sex selection, PGD is useful for eliminating sex-linked hereditary diseases

Who can benefit from PGD?

  • Carriers of sex-linked genetic disorders
  • Carriers of single gene disorders
  • Those with chromosomal disorders
  • Women over the age of 35
  • Women who have experienced recurrent miscarriages
  • Couples that are carriers of sex-linked genetic disorders
  • Parents who have a child with a serious genetic condition, but want to get pregnant again

PGD at The Bridge Clinic

In an effort to stay abreast of international medical innovation, The Bridge Clinic now offers PGD as a specialised service forming part of Advanced Care. Our affiliation with IVF Centers Prof. Zech in Austria sees to it that our physicians are trained internationally and remain at the cutting edge of new technology and procedures in the field of genetics.

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Visit any of our clinics in Lagos, Abuja or Port Harcourt or call the central call line on 0810 460 7790.